Advances in Tissue Repair and Regeneration
MENG Xinan1, XU Jingxiu2, XU Suhong1,2*
Tissue repair and regeneration is one of the complicated biological processes and important biomedical questions in the life science. Rapid wound response can be found in any tissue or organ, that changes a variety of cell fate properties to achieve wound repair and regeneration by triggers endogenous gene transcriptional regulation. Most human tissues and organs do not have the ability to regenerate lost one, however, many animals in early evolutionary, as well as most plants, have strong regenerative capabilities. Through the study of different model organisms, with the development of single-cell sequencing technology, through genetic tracing and in vivo imaging, we are starting to understand the key cell types and underling molecular and cellular mechanism during the tissue regeneration. This review will provide a brief summary of the key cell sources of wound repair and regeneration, post-injury gene transcriptional regulation, and rapid wound stress. Due to limited space, we are unableto cover all the research studies in the field of tissue repair and regeneration.
CN
EN