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Function and Application of Heparin Sulfate in Cancer
Wu Rui, Xiao Rong, Wang Jihong*
(College of Life Sciences, Liaoning Normal University, Dalian 116029, China)
Abstract:
Heparan sulfate is widely distributed in various tissues of the human body in the form of proteoglycans. Heparan sulfate binds to proteins to produce heparan sulfate proteoglycans, to regulate various physiological processes of the body and play an important role in the occurrence and development of cancer. This article reviews the structural characteristics of heparan sulfate and its proteoglycans, their correlation with the development of cancer, and the cancer treatment strategy targeting heparan sulfate/heparan sulfate proteoglycan, in order to provide reference for relevant basic research and new drug development.
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