Research Progress of lncRNA in Pluripotent Stem Cells

Liu Fang, Xiang Jinzhu, Li Xueling*

(State Key Laboratory for Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010070, China)

Abstract:

Pluripotent stem cells (PSCs) can proliferation, self-renew and differentiate without restriction, most commonly refer to embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), which have received extensive attention in modern biology. Studies have shown that the maintenance of pluripotency of PSCs is regulated by a variety of factors, such as the common regulation of transcription factors and non-coding RNA. Long non-coding RNA (lncRNA) as a new regulatory molecule has become a new research hotspot. lncRNA is a type of RNA molecule with more than 200 nt of transcripts, which exists in the nucleus or cytoplasm but cannot encode proteins. play important regulatory roles in many biological processes of PSCs particularly during the process of cell self-renewal and differentiation. This review will focus on the research progress of in the maintenance and differentiation of PSCs based on the latest reports.

CSTR: 32200.14.cjcb.2019.08.0023