Progress in the Study of Non-Coding RNA and Gestational Diabetes Mellitus

Yao Binbin^1#, Zhu Qiong^2#, Chen Yanming¹, Xu Jin¹, Ji Lindan^3,4*

(¹Department of Preventive Medicine, Ningbo University Medicine, Ningbo 315211, China; ²Yinzhou Hospital, Ningbo University Medicine, Ningbo 315040, China; ³Department of Biochemistry and Molecular Biology, Ningbo University Medicine, Ningbo 315211, China; ⁴Zhejiang Key Laboratory of Pathophysiology Technology Research, Ningbo 315211, China)

Abstract:

Gestational diabetes mellitus (GDM) is a common pregnancy complication that refers to spontaneous glucose intolerance first occurs or diagnosed during pregnancy. In recent years, studies have found that a large number of non-coding RNAs (ncRNA) are involved in the development of GDM, including microRNA (miRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA). This review focuses on the biological roles of miRNA, lncRNA and circRNA in the development and progression of GDM, which helps us better understand the molecular mechanisms by which ncRNAs function and interact with each other in GDM, providing further information for future research.

CSTR: 32200.14.cjcb.2019.08.0021