Role of Hedgehog Signaling Pathway in Regeneration of Liver Injury
Jin Lifang, Ni Jian, Yan Junyan, Han Jiwei, Hu Baowei*
Hedgehog (Hh) signaling pathway, an important morphogenetic factor in embryonic development, is silenced in adult liver and becomes activated in many types of liver injuries. Hh signaling pathway is involved in the repair of liver injury in various aspects, including proliferation and differentiation of hepatic stem/progenitor cells, vascular remodeling of hepatic sinusoidal endothelial cells, inflammation response of immune cells, and activation and fibrosis of hepatic stellate cells. This paper summarizes the researches about role of Hh signaling pathway-mediated liver injury repair, which will provide a theoretical basis for promoting advances in liver disease therapy.
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