The Role of Nrf2 in Tumor Chemoresistance and Drug Resistance
Zhou Jingwei, Zhu Xiaokuan, Cheng Ran, Yang Xinhui, Xu Jiaqian*, Cai Rong*
The Nrf2 [nuclear factor erythroid 2 (NFE2) related factor 2] is a nuclear factor that regulates the transcription of downstream genes via Keap1-Nrf2-ARE pathway to protect cells against oxidative stress, and cytotoxic agents. However, in tumor cells, the existence of Nrf2 promoting tumor growth and their resistance to chemo-therapy drugs, has brought enormous difficulties to clinical treatments. Thus, recently, researches have been increasingly conducted upon the relations of Nrf2 and chemoresistance in tumors. In this review, we provide an updated overview on tumor chemoresistance linked with Nrf2 and its underlying mechanism, in order to offer a deeper perception for further clinical research and practice.
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