Endoplasmic Reticulum and Oocyte Development
Jia Zhenwei*, Yang Xinyu
The endoplasmic reticulum (ER), an important organelle of mammalian cells, is a key modulator that regulates calcium homeostasis, protein folding and signal transduction. Somes studies have shown that the variation of ER distribution and structure during oocyte maturation, the ability of ER to store and release Ca2+ as well as environmental stress-induced ER stress play an important role in oocyte maturation and development competence. Therefore, in this review, we summarize current knowledge on the variation of ER distribution and structure during oocyte maturation, the relationship between ER and calcium oscillation in oocytes as well as the effects of ER stress on oocyte developmental competence, which may provide reference for further understanding the role of ER in regulating oocyte maturation and developmental competence, thereby helping researches in reproductive biology.
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