Regulation of Adipogenesis in Animals by Curcumin
Zheng Juanjuan, Li Ying*
The proliferation and differentiation of adipocytes, which increase the number of the cells and the the size of a single cell, lead to the deposition of adipose tissue in living animals, and the degree of obesity is determined by the fat cells’ number and size. The direct result of adipocyte apoptosis is a decrease in the number of fat cells, which in turn reduces the amount of adipose tissue in vivo. Curcumin is a kind of natural yellow polyphenols extracted from turmeric rhizome, and it has strong biological activity. Curcumin can regulate the development process of adipocytes, turn white adipocytes into beige cells, and improve endoplasmic reticulum stress, lipid metabolism disorder, glucose metabolism disorder caused by obesity and obesity-related inflammation in body. The recent progress about the effects of curcumin on the proliferation, differentiation, apoptosis , lipid metabolism of adipocytes and the signaling pathways involved in these processes were summarized, and the effects of curcumin on the prevention and treatment of obesity and its complications were discussed in this review. It may provide a useful reference for researchers’ working in this field.
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