Metabolic Regulations in Hematopoietic Stem Cells
Chen Chiqi#, Huang Dan#, Hao Xiaoxin, Gu Hao, Xie Li, Yu Zhuo, Zheng Junke*
Hematopoietic stem cells (HSCs) are one of the important adult stem cells, which can further self-renewal and differentiate to all the blood cell types. HSCs have been widely used for the treatments of many hematopoietic disorders. Increasing evidence shows that many intrinsic and extrinsic regulatory factors are involved in the cell fate determinations of HSCs, although the underlying mechanisms remains largely unknown and may impede the HSC applications in the clinic. In this review, we summarize the current findings in HSC metabolisms and its related regulatory networks: adult HSCs reside in the relatively hypoxic bone marrow niches and prefer to utilizing glycolysis as the main energy sources; oxidative phosphorylation may also play a role in HSC activities; other nutrient metabolisms (such as lipid and amino acid) are reported to be critical for HSC stmenss as well; MEIS1/HIF1A and ROS signals have been found to be critical in the maintenance of HSC metabolic profiles and activities; it is urgent to develop novel precise metabolic techniques withlimited HSC amounts, which will definitely benefit for the understanding the temporal and spatial metabolic properties of HSCs.
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