Metabolic Remodeling in Cancer
Zhao Mengjia#, Mao Youxiang#, Xu Chang#, Yao Pengbo#, Jiang Peng*
Oncogenic mutation has been thought to be tightly associated with the onset and development of cancer. Emerging evidences suggest that cancer cells frequently reprogram metabolic pathways to meet their high demands of biogenesis and rapid proliferation. Metabolic remodeling is connected with oncogenic alterations and affects epigenetic modification and gene expression. Dysregulation of metabolism ultimately influences cancer cell fate decision. Thus, understanding how key metabolic pathways, such as glucose catabolism, amino acid, nucleotide biosynthesis, and lipid metabolism, are aberrantly regulated, and what advantages these metabolic changes confer to cancer cells are of great interest and may benefit the follow-up research and therapeutic targeting.
CN
EN