Immune Cell Metabolism and Its Regulation
Geng Jing*, Li Jiaxin, Nian Cheng, Yang Bingying, Zhou Dawang*, Chen Lanfen*
The immune system defends against pathogens and maintains tissue homeostasis throughout the life of the organism. These diverse functions require precise control of cellular metabolic pathways. Studies over the past decade have elucidated the molecular basis for how extracellular signals control the uptake and catabolism of nutrients in quiescent and activated immune cells. Here, we discuss these findings and provide a general framework for understanding how metabolism fuels and regulates the proliferation, differentiation and function of immune cells. A better understanding of the function of metabolites in immune cells that control these transitions might provide new insights into modulating immunity in infection, cancer, or inflammatory disorders.
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