Home > Browse Issues > Vol.41 No.7
Regulation of Hepatic Gluconeogenesis
Han Jinbo, Wang Yiguo*
(MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China)
Abstract:
Gluconeogenesis in the liver maintains glucose homeostasis, while enhanced gluconeogenesis is one of the hallmarks of type 2 diabetes. Here, we review the molecular mechanisms controlling hepatic gluconeogenesis and assess the current drugs to treat type 2 diabetes, focusing on the therapeutically targeted pathways that are associated with hepatic gluconeogenesis.
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