Research Progresses of Carboxyterminus of Hsp70 Interacting Protein (CHIP), A key Factor in Keeping Cellular Proteostasis
Su Yongnan, Wang Yuling, Song Bin, DuanWenfang, YangFan, Zhang Jihong*
The development of life activities within organisms is based on the maintenance of cellular proteostasis. E3 ubiquitin ligase carboxyterminus of Hsp70 interacting proteinas (CHIP) is a key regulator in protein quality control system, can maintain a balance between protein folding and its degradation by cooperation with the heat shock proteins. Furthermore, CHIP can protect organisms from protein toxicity through the autophagy pathway or by virtue of intrinsic chaperone activity. Owing to the target proteins of CHIP such as mutp53 are associated with significant biological events even affect cancer, cardiovascular diseases and other diseases. Therefore, study the mechanism for CHIP to regulate the cellular protein homeostasis and clarify the role of CHIP in the development of various diseases, can provide a theoretical basis for prevention and treatment of protein metabolism disorder related diseases.
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