MiRNAs Are Involved in the Occurrence of Aneurysm as an Important Regulator of Vascular Homeostasis
Cui Yan, Kong Peng, Han Mei*
Aneurysms are asymmetrical dilations of the aorta with diameters>1.5 of times the normal size. Currently, the only available treatment of aneurysms is surgical intervention. MiRNAs are a class of single-stranded, non-coding RNAs with a length of approximately 22 nucleotides that usually bind to the 3′untranslated region (UTR) of the target gene mRNA and regulate gene expression at the post-transcriptional level. Previous researches have shown that miRNAs are involved in the process of aneurysm formation and development. This review summarizes the currently available data regarding the involvement of miRNAs in aneurysms.
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