Deubiquitinase and Cell Cycle Regulation
Wei Dong, Deng Tanggang, Ye Mao*
Ubiquitination is an important modification of protein translation. Through ubiquitination, proteins are labeled with polyubiquitinated chains that are recognized by the proteasome and cause degradation. The cell cycle is the basis of cell proliferation, and ubiquitin-mediated protein degradation plays an extremely important role in driving the orderly operation of cell cycle in eukaryotes. In recent years, studies have shown that ubiquitination is a reversible process. Deubiquitinase can reverse the ubiquitination process and stabilize proteins, and are closely related to the regulation of cell cycle phases. Therefore, the recent advances of deubiquitinases in cell cycle regulation are reviewed.
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