Epigenetic Regulation of Stem Cell Aging

Hu Huifang^1,2, He Zhiheng^2,3, Qu Jing^1,2, Zhang Weiqi^2,4*, Liu Guanghui^1,2,3*

(¹Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; ²University of Chinese Academy of Sciences, Beijing 100101, China; ³Institute of Biophysics,Chinese Academy of Sciences, Beijing 100101, China; ⁴Beijing Institute of Genomics, Chinese Academy of Sciences Beijing 100101, China)

Abstract:

Aging is a process along with multiple tissues and organs injuring, finally leads to cell and individual death. Stem cell exhaustion, dysfunction and altered epigenetic states are considered as driver of aging, Altered epigenetic states are more inportant than genes to regulate life span. Dietary habit, exercise and other methods can change epigenetic states to affect life span. Epigenetic regulation includes DNA methylation, histone modification, chromosome remodeling, non-coding RNA, etc. Here, we focused on current knowledge about stem cell senescence and try to discover the possible intervention means to achieve healthy aging even delay aging in the future.

CSTR: 32200.14.cjcb.2019.06.0003