Advances in Research and Application of Hematopoietic Stem Cells
Tian Xiaoling, Yang Fei, Wu Yuxuan*
Multipotent hematopoietic stem cells (HSCs) reside in specialized niche mainly in adult bone marrow with extensive self-renewal and differentiation capacity, can replenish all myeloid and lymphoid blood cell lineages and maintain blood system establishment and dynamic balance. Due to these important characteristics of HSCs and extensive clinical application of HSC transplantation, combined with advances in gene therapy and gene editing, the research of HSCs based gene therapy for many blood diseases and immune diseases has made great progress in recent years. In this review, we focus on self-renewal and differentiation of HSCs, sources and microenvironment of HSCs, gene editing based clinical research with HSCs especially for beta-Thalassemia.
CN
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