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Plant D-type Cyclins
De-Xi Chen, Bing-Tian Ma, Shi-Gui Li*
Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China
Abstract: D-type cyclin (cyclinD， CycD) regulates the G1/S transition. Under the stimulation of the exogenous signals， CycD accumulates and binds to cyclin dependent kinase (CDK) to form active complexes， which phosphorylate the retinoblastoma (Rb) protein. Rb phosphorylation results in releasing the transcription factor E2F and thereby drives the G1/S transition. The control pathway is conserved in all higher eukaryotes. CycDs are different from other cyclins， because their expression is not tightly cell-cycle-regulated， but rather is activated by growth factors and decline rapidly when the mitogenic signal is removed， therefore the cell is arrested in G1. Many analyses showed that CycDs are crucial growth factor sensor， the expression of these genes affects plant development. Here we reviewed the characteristics and roles in cell cycle of plant CycDs， and discussed their functions in plant development.
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