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The Research Progress of Oxytocin in Pain Modulation Mechanism
Hu Lingjie, Hu Qianyu, Shen Sihong, Jie Junjin, Chen Xiaowei*
(Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China)
Abstract:
Pain is an unpleasant subjective feeling and emotional experience associated with tissue damage or potential tissue damage. However, current clinical anti-nociceptive treatments are not satisfactory yet. Therefore, finding new strategies of pain treatment has become a hot and essential topic of pain research. In recent years, oxytocin has been found to have analgesic effects on different types of pain via both central and peripheral mechanisms. This article summarizes recent clinical and basic research advances and the associated regulatory mechanisms of oxytocin in the pain therapy.
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