Home > Browse Issues > Vol.41 No.4
The Roles of Sirtuins and Autophagy in Oocyte Aging
Liu Erzhen, Liu Zhaojun, Meng Meng, Shen Xinghui, Lei Lei
(Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China)
Abstract:
Long-term unfertilized oocytes inevitably undergo nuclear and cytoplasmic aging, which will lead to fertilization and development defects. Sirtuins is a NAD+-dependent histone deacetylase, through regulating the metabolism of cells aging delaying and inhibiting effects. In this review, we summarized the changes of aging oocytes in nucleus and cytoplasm. In addition, the functions of sirtuins, the relationship between sirtuins and postovulatory aging, and relationship between sirtuins and autophagy. It is also discussed that the regulation of sirtuins may delay and improve the aging of oocytes.
CN
EN