Progress of the Role-Aryl Hydrocarbon Receptor on Dendritic Cell

Liu Yijia^1,2, Yu Jing¹, Liang Huaping¹, Li Suiyan², Yan Jun¹*

(¹State Key Laboratory of Trauma, Burns and Combined Injury, Department 1, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing 400042, China; ²School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China)

Abstract:

As the strongest antigen presenting cell (APC) in vivo, dendritic cell (DC) is a bridge between innate and adaptive immunity. Furthermore, it plays an important role in triggering and amplifying the signals of immune response. Recent studies showed that aryl hydrocarbon receptor (AhR) can regulate the immune functions via DC, and may be a potential key molecule of immune modulation to participate in the prevention and cure of immune dysfunction caused by various injuries and diseases. This review summarized the role and regulatory mechanism of AhR on DC according to the related reports for the past few years, so as to provide the literature evidence and new idea to investigate the key molecule for immunomodulation.

CSTR: 32200.14.cjcb.2019.04.0022