Tubulin Isotype and Its Function
Diao Lei1, Liu Mingyi2, Bao Lan1,2*
Microtubules are the main cytoskeleton in almost all eukaryotic cells and composed of α/β tubulin. They play critical roles in various cellular processes. The functions of microtubules are regulated by microtubule- interacting proteins， tubulin post-translational modifications and tubulin isotypes. Previous studies have reported several isotypes of α/β-tubulin. The expression patterns of tubulin isotypes vary widely among different tissues and during development stages. Mutations in a variety of tubulin isotypes are able to cause nervous system diseases. Here， we review the research progress on tubulin isotypes， especially their roles in the regulation of microtubule function， the development of nervous system and related diseases.
CN
EN