Research Progress of Exosomes in the Diagnosis and Treatment of Tumors

Abstract: Exosomes are transport vesicles with a size of 30-130 nm， which are secreted by cells and possessed the biological characteristics of donor cells. As an important medium for information transmission and material exchange among cells， exosomes contain proteins， RNA and other biologically active molecules and play an important role in the development of normal physiological metabolic reactions， tumors and other diseases. As a new natural endogenous material transport carrier， exosomes have the advantages of low toxicity， low immunogenicity， and good permeability. Currently， exosomes have been successfully loaded with small molecule chemical drugs， genes and other biologically active molecules for the diagnosis and treatment of cancer. This article reviews the biological characteristics of exosomes， the advantages of exosomes as diagnostic biomarkers and drug carriers， and the application in tumor diagnosis and treatment.

CSTR: 32200.14.cjcb.2019.03.0023