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Comprehensive Diagnosis and Analysis of Virus E2 Gene in Typical Cases of Classical Swine Fever in a Swine Farm
Li Yan1, Ma Zicheng1, Liu Zhaohu1, Wang Hongyu1, Meng Fanliang1, Cao Longlong1, Jiao Qiulin1, Liu Mengda1, Li Baoquan1*, Liu Sidang1,2,3*
1College of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China; 2Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian 271018, China; 3Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Shandong Agricultural University, Taian 271018, China
Abstract: In July 2018， a deathful disease outbroke in a fattening pigs farm in Shandong province. Clinical symptoms included high fever， flushed skin with dotted bleeding. It was preliminarily diagnosed as Classical Swine Fever (CSF) after autopsy and a comprehensive laboratory detection. Then， the E2 gene of Classical Swine Fever virus (CSFV) was detected and sequenced. This outbreak was confirmed as infection of CSFV. The nucleotide sequence homology between the strain in this study (named SDXT2018) and reference strains was from 81.3% to 96.2%. In reference strains， SDXT2018 was closest to JQ001834 that belongings to 2.1d subtype. The homology between SDXT2018 and AF091507， which was classical attenuated hog fever vaccine strain， was just 81.3%. The results showed variation of the epidemic strains of CSFV in China is becoming severe， which seriously threat the
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