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The Signal Regulatory Mechanism and Function of Actin Filaments
Lu Yunkun1, Xie Shanshan1,2*, Zhou Tianhua1,3*
1Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China; 2The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China; 3Joint Institute of Genetics and Genomic Medicine between Zhejiang University and University of Toronto, Hangzhou 310058, China
Abstract: Actin filaments are one of the main component of the cytoskeleton， which are widely exist in all eukaryotic cells. Actin filaments and actin-associated proteins-mediated signaling pathways play important roles in many cellular biological events， including cell morphology maintain， cell motility， signal transduction. Actin filaments and actin-associated proteins also play a key role in development， and their abnormality is associated with disease. In this review， we summarized the latest advance of actin， actin-associated proteins， actin-related signaling pathways and their correlation with diseases. We also preliminarily discussed the future research direction of actin filaments.
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