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Alveolar Epithelial Cell II Transdifferentiation
Hong-Yan Lu*, Li-Wen Chang
Department of Pediatrics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430030, China
Abstract: The mammalian pulmonary alveolar epithelium is comprised of two types of cells， called alveolar epithelial cell II (AECII) and alveolar epithelial cell I (AECI). AECII can transdifferentiate into AECI to repair damaged epithelium after lung injury or during fetal lung development. AECII grown in primary culture can be observed to undergo such a transition in vitro. This review hereby summarizes the presentation， influences and regulation of AECII transdifferentiation and its roles in lung injury.
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