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Regulation of Microtubule Dynamics and Functions by Post-Translational Modifications and Microtubule-Binding Proteins
Xie Songbo1*, Zhou Jun1,2*
1College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, China; 2College of Life Sciences, Nankai University, Tianjin 300071, China
Abstract:
Microtubules are highly dynamic cellular structures， and the dynamic property of microtubules is essential for various cellular activities. Microtubule-binding proteins play important roles in regulating microtubule dynamics and microtubule-mediated cell activities. The interaction of microtubule-binding proteins with microtubules is regulated by post-translational modifications of tubulin. In this review， we discuss how tubulin post-translational modifications and microtubule-binding proteins affect microtubule dynamics and microtubule-mediated cellular activities.
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