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Relativity about Gap Junctions and Human Genetic Diseases
Hong Lu, Zheng-Hao Huo*
Department of Medical Genetic and Cell Biology, Ningxia Medical College, Yinchuan 750004, China
Abstract: Gap junctions were the hydrophilic trans-membrane channels formed by the multipled connexin family. To the date， approximately 20 connexin genes were identified in mouse while 21 connexin genes in human genome， 19 of which would be expressed in both and showed high homologues. Homomeric and heteromeric were the two type connexons formed from different connexins， there were four types gap junction channels formed from different type connexins. More and more researches showed that connexin genes mutations were closely associated with human genetic diseases.
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