The Research Progress of Autophagy
Li Yixing, Yao Weijing, Yi Cong*
Autophagy is a highly conserved lysosome-based intracellular degradation pathway in eukaryotes, which plays an important role in maintaining the steady-state balance between cells and organisms. Researches have shown that autophagy is involved in many processes, such as biological development, immune response, metabolic regulation, apoptosis and aging etc. Dysfunction of autophagy is closely related to the occurrence and development of neurodegenerative diseases and tumors. In the past 30 years, autophagy has made great progress in molecular mechanism and physiological function. To further deepen our understanding about autophagy, this review mainly focuses on the concept of autophagy, the composition and regulation mechanism of autophagy core machinery, autophagy types, physiological functions, and related diseases.
CN
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