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The Mechanism of Translation Control by eIF4E Inhibitory Proteins
De-Li Xu*
eukaryotic messenger RNAs; eIF4E; eIF4E inhibitory proteins; translation control
Abstract: Translation control of eukaryotic messenger RNAs often occurs in the initiation step. The binding of eIF4E， which is one component of the heterotrimeric eIF4F complex， to the mRNA 5' cap structure is the focal point for initiation. It is through its interaction with eIF4E that eIF4E inhibitory proteins regulate the translation rate. This translation control of eIF4E inhibitory proteins has a great impact on such processes as cell growth， development， cancer and neurobiology. This paper mainly reviews the molecular mechanisms by which eIF4E inhibitory proteins control translation.
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