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Progress on the Effects of Protein Phosphatase 2A on Insulin Regulation
Chen Kele, Huang Pu, Xu Lihong*
Department of Biochemistry, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Numerous protein phosphorylation and dephosphorylation are involved in insulin secretion and insulin signaling pathway. Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases in eukaryotic cells， and its role in metabolic disease is given more and more attention. So far， studies have shown that PP2A affects the secretion of insulin and the response of peripheral tissues to insulin， insulin also affects the activity and protein level of PP2A. The relationship between PP2A and insulin resistance has also become a hot topic in recent years. This article reviews the role of PP2A in insulin regulation， which might help to give researchers a further understanding of its important role in insulin regulation.
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