A Review of the Research on the Correlations Between Lung Cancer and Chronic Obstructive Pulmonary Disease

Chen Shi1, Tang Tao2, Li Tingting1, Guo Liqiong1, Kong Xiangyang1*

1Department of Medical Genetics and Pharmacogenomics, Medical Faculty of Kunming University of Science and Technology, Kunming 650504, China; 2Teaching and Researching Section of Rehabilitation, Medical Faculty of Kunming University of Science and Technology, Kunming 650504, China

Abstract: Many epidemiological studies have linked the development of lung cancer with the existence of chronic obstructive pulmonary disease (COPD)， both of which are symbolized by high morbidity and mortality. Research shows that lung cancer and COPD have common pathogenic factors， and COPD is listed as one of independent risk factors causing lung cancer. There is an ever-growing bundle of evidence that suggests a close association between persistent chronic inflammation， COPD and lung cancer. A few potential targets of genetic susceptibility locus for COPD and lung cancer have been suggested. This article reviews the research on the potential common pathogenesis of lung cancer and COPD to explore whether COPD can be a pathogenic factor for lung cancer.

CSTR: 32200.14.cjcb.2019.01.0014