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Structure and Functions of CIN85
Fang Huang*, Min-Juan Bian
State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Abstract: CIN85 and CD2AP comprise a new family of adaptor proteins that plays important roles in animal development and diseases. They share a high sequence similarity in several functional domains that exhibit unique scaffolding function. Recent data suggest that the scaffolding function of CIN85 may control multiple cellular functions， such as down-regulation of receptor tyrosine kinases (RTK)， regulation of apoptosis， and modulation of cell adhesion.
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