Advance in Extracellular Vesicles and Autophagy for Osteoarthritis

Li Hui1, Zhang Miao1, Wu Wei1, Guo Jianmin1, Zou Jun1,2, Wang Miao1,3*

1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; 2Development and Planning Office, Shanghai University of Sport, Shanghai 200438, China; 3Department of Sport Rehabilitation, Shanghai University of Sport , Shanghai 200438, China

Abstract: Osteoarthritis (OA) is a chronic joint disease characterized by the degeneration and loss of articular cartilage， synovial and subchondral bone hyperplasia， which seriously affect the quality of patients life. Previous studies have shown that the pathogenesis of OA is related to age， joint biomechanical changes， inflammatory factor erosion， immune response and joint trauma. However， the specific pathogenesis of OA has not been explained. Recent studies have found that both extracellular vesicles (EVs) and autophagy play important role in the proliferation and homeostasis of OA， but lack systematic and completely discussion. Therefore， in this work， the effect on the proliferation and differentiation of OA chondrocytes and autophagy to regulate the homeostasis of chondrocytes of EVs， which derive from chondrocytes， synovial cells and mesenchymal stem cells are reviewed. We aims to review the latest research progress in OA from the aspect of EVs and autophagy， which may provide possible theoretical basis and strategies for the diagnosis and treatment of OA.

CSTR: 32200.14.cjcb.2018.12.0017