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The Roles and Mechanisms of Olfactory Epithelial Basal Cells in the Olfactory Regeneration and Repair
Shu Pingping1, Zhou Junlei1, Liang Yi1, Bao Xiaomei2, Huang Zhihui2*
1First Clinical Medical College, Wenzhou Medical University, Wenzhou 325035, China; 2Institute of Neuroscience, Department of Basic Medicine, Wenzhou Medical University, Wenzhou 325035, China
Abstract: The olfactory sensory neurons (OSNs) in the olfactory epithelium are exposed directly to the external environment， making them susceptible to damage， even to death， but the olfactory epithelium can regenerate itself for a lifetime to slow down the degeneration of olfactory system. The ability of regeneration of olfactory system mainly depends on the olfactory epithelial stem cells， globose basal cells (GBCs) and horizontal basal cells (HBCs). This review focuses on the recent studies on these two cells about their roles and mechanisms in normal olfactory epithelial regeneration and response to injury repair， to provide insights into the treatment of olfactory dysfunctions and explore the potential of their application in the treatment of central nervous system.
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