Home > Browse Issues > Vol.40 No.12
Effects of DNA Methylation on the Cell Cycle
Dong Suohua1, Wang Fang2, Bao Jinfeng1*
1Basic Medical School, Inner Mongolia Medical University, Huhhot 010110, China; 2Department of Pharmacy, the People’s Hospital of Shanting District, Zaozhuang 277200, China
Abstract: Cell cycle is a very complex and precise regulation process， which is continuous and irreversible. Cell cycle disorder is an important pathology for cancer and age-related diseases. Recently， epigenetics may be changed through cell division and proliferation and stable genetic phenomenon. DNA methylation is the most common epigenetic modification. DNA methylation plays a critical role in the regulation of gene transcription， genome stability， cell cycle and so on. The data found that epigenetic pattern abnormal caused the cell cycle disorder is an important mechanism for cancer and age-related diseases. DNA methylation can affect cell cycle by regulating the key factors of cell cycle regulation. In this paper， the effects of DNA methylation on the cell cycle are reviewed， in order to provide a theoretical basis for improving the clinical diagnosis and treatment of tumors and other diseases in the future.
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