Home > Browse Issues > Vol.40 No.12
Progress of LIMK1/Cofilin Signal Pathway in Alzheimerʼs Disease
Lin Danfeng, Zhao Dongyue*
Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China
Abstract: Abnormal Cofilin-rods (hirano bodies) are the prominent pathological features in Alzheimer’s disease brains besides amyloid plaques and Tau neurofilamentous tangles. Based on that the drugs targeting β-amyloid protein were unsuccessfully designed， the involvement of Rac1/PAK/LIMK1/Cofilin signaling pathway in AD pathogenesis has become a “hot” research spot in recent years. Therefore， the regulated relationship of between the Rac1/PAK/LIMK1/Cofilin pathway and F-actin dynamics can further to reveal the pathogenesis of AD and discover the drug targets against AD.
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