One-Carbon Metabolism and Anti-Folate Chemotherapeutic Drugs

Abstract: One-carbon metabolism not only provides cellular components， including nucleotides， lipids and proteins， for cell growth， but also generates glutathione and S-adenosylmethionine to maintain the cellular redox status and epigenetic status. One-carbon metabolism involving folic acid cycle and methionine cycle， satisfies the requirments of cell growth and proliferation. Recently， metabolic reprogramming is the hallmark of tumor cells. Chemotherapeutic drugs directly targeting the enzymes involved in one-carbon metabolism and nucleic acids metabolism have raised a surge of interest. This review focuses on the recent developments in our understanding of one-carbon metabolism， and has led to the new recognition of relationship between metabolism and cancer biology.

CSTR: 32200.14.cjcb.2018.12.0001