Home > Browse Issues > Vol.40 No.11
Research Progress on Long Non-Coding RNA TUG1 in Human Cancers
Zhou Hui1, Gao Zixu1, Xie Zheng1, Wan Fusheng2*
1The Second Clinical Medical College of Nanchang University, Nanchang 330006, China; 2Department of Biochemistry and Molecular Biology, Medical College of Nanchang University, Nanchang 330006, China
Abstract: Long non-coding RNAs (lncRNAs) are RNAs that are longer than 200 nucleotides， which lack protein coding ability. Long non-coding RNA taurine upregulation gene 1 (TUG1) is a cancer-associated lncRNA. It has been considered previously that TUG1 is closely related to the occurrence， invasion， and metastasis of cancers. In recent years， it has been found that TUG1 can promote target gene expression， affect tumor angiogenesis， and act as a competitive endogenous RNA (ceRNA) by recruiting certain RNA-binding proteins. TUG1 is expected to be a biomarker or a therapeutic new target for the diagnosis and prognosis of certain cancers. This article reviews the role of TUG1 in the development of human cancer.
CN
EN