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The Development and Application of Blood Biomarkers in Molecular Diagnosis and Treatment of Alzheimer’s Disease
Zhao Dongyue, Lin Danfeng*
Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China
Abstract: The means used for personalized diagnosis and intervention of Alzheimer’s disease (AD) is currently lacking. Therefore， it is urgent to develop biomarkers for blood biomarkers for personalized diagnosis. To solve this problem， validated plasma biomarkers with emphasis on the factors involved in inflammation and immune-suppression will possibly be screened. The potential blood biomarkers will be further confirmed by investigating the link between these biomarkers and AD-associated genetic risk factors to explore the possibility of personalized molecular diagnostics in AD. The study described in above will provide significant evidence for the personalized clinical use of blood biomarkers and may lead to the discovery of novel therapeutic target for preventing or treating AD.
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