Home > Browse Issues > Vol.40 No.11
Limb Regeneration under Check by the Nervous System
Lin Gufa*, Chen Ying
Research Center for Translational Medicine at Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China
Abstract: Salamanders and Xenopus tadpoles can fully regenerate the limb after amputation， and this regeneration depends on the presence of a certain amount of nerve tissues. Since the discovery of nerve dependent limb regeneration in 1822， there has been extensive interest in identifying the molecules mediating the effect of nerves for limb regeneration， a mission yet to be accomplished. Here we briefly review the history of study on nerve dependent limb regeneration， and provide a potential avenue for understanding limb regeneration under regulation by the central nervous system， as indicated by our recent finding on a role of the melanocortin receptor signaling in Xenopus limb regeneration.
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