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The Regulatory Role of Ski in Cell Proliferation， Transformation， Collagen Secretion and Inflammatory Response
Li Ping, Zhou Yuanguo*
The Molecular Biology Center, State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing 400042, China
Abstract: ski gene is known as the cellular homologue of the avian sarcoma viral oncogene (v-ski). The protein encoded by ski gene is a multifunction regulatory factor in many physiological and pathological processes， which has been reported to be involved in hematopoietic cell proliferation， muscle regeneration， the development of bone and nervous system， synaptic projection， wound healing and fibrosis and tumor growth. These effects are related to a large number of transcription factors and transcriptional co-regulators that interact with Ski by many signaling pathways. Therefore， this article will introduce the regulatory roles and mechanisms of Ski in cell proliferation， transformation， collagen secretion and inflammatory.
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