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Application of Animal Models in Neurodegenerative Diseases
Yuan Yijiao, Chen Shi*
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
Abstract: The main clinical symptoms of neurodegenerative diseases contain memory loss， cognitive impairment， loss of motor ability， and loss of sense. As the ageing of the population intensifies worldwide， its incidence rate increases. Due to its complex pathogenesis and manifestations， our knowledge of these diseases is still shallow， and the corresponding methods of treatment are scarce. The extensive use of animal models in the study of neurodegenerative diseases provides us with good experimental materials. This review summarizes the successful constructed animal models in Alzheimer’s disease， Parkinson’s disease， Huntington’s disease and amyotrophic lateral sclerosis. Animal species involved include Caenorhabditis elegans， Drosophila melanogaster， zebrafish， rodents， minipigs and non-human primates.
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