Home > Browse Issues > Vol.40 No.9
The Application of Induced Pluripotent Stem Cells in Studying Neuropsychiatric Disorders
Shen Luping1#, Dong Ying2#, Zhang Shasha2, Hu Yao1, Chai Renjie2*, Liu Yan1*
1School of Pharmacy, Nanjing Medical University, Nanjing 211100, China; 2Institute of Life Sciences, Southeast University, Nanjing 210096, China
Abstract: Neuropsychiatric disorders， including more than 400 diseases such as depressive disorder， bipolar affective disorder， dementia， developmental retardation and schizophrenia， imposes heavy social and economic burdens on individuals， communities and countries. Although numerous studies have made enormous progress on these diseases over the last few decades， the mechanisms of diseases still remain unknown. More and more studies have shown that the induced pluripotent stem cells (iPSCs) technology could simulate the dynamical changes during the process of central nervous system disease. In this review， we introduced iPSCs technique and enumerate current researches of neuropsychological diseases using iPSCs technique. We also discussed the technique of three-dimensional culture of stem cells and put forward several hot spots need to be further researched in this field.
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