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The Research Progress of miR-21 in Head and Neck Cancer
Wu Linrong1,2, Hao Wenjuan1,2, Liu Weihong1, Shen Zhisen1,2*, Deng Hongxia2
1Ningbo University School of Medicine, Ningbo 315211, China; 2Ningbo Medical Centre of Lihuili Hospital, Ningbo 315040, China
Abstract: MicroRNA (miRNA) is a kind of small non-coding RNA， which can cause degradation or translation inhibition of target miRNA， and thus， it regulates the expression of genes after transcription. It plays an important role in cell growth， development and aging. miR-21 is one of miRNA which was found earlier and exists extensively in human tissues and cells， and is also one of the most common overexpressed miRNA in solid tumors. It may play a role as an oncogene in the development of tumors. This article reviews the research of miR-21 in head and neck tumors.
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