Home > Browse Issues > Vol.40 No.8
Regulation Mechanisms of Tongue Development
Li Yan, Yu Jiaojiao, Li Haoran, Li Feixue*
College of Life and Environmental Science, Hangzhou Normal University, Hangzhou 310036, China
Abstract: Tongue is an important organ involved in chewing， swallowing， pronunciation. Abnormal tongue development will lead to aglossia， microglossia， bifid tongue， ankyloglossia， macroglossia and cleft palate. The normal tongue is composed of muscle， connective tissue， mucosal tissue and blood vessels. Paired box gene Pax3 and Pax7， Dlx genes， TGF-β and FGF genes have been proved to be critical for tongue development. Shh and Wnt signaling pathways are also involved in the regulation of tongue development. The study of molecular mechanism will contribute greatly to the diagnosis and treatment of diseases of tongue development.
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