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Effect of Exosomes on Osteoarthritis
Zhou Xuchang1, Li Hui1, Zou Jun2, Wang Miao1*
1School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China; 2Development and Planning Office, Shanghai University of Sport, Shanghai 200438, China
Abstract: The occurrence of osteoarthritis (OA) mainly associated with intra-articular biomechanics changes， cartilage damage and synthetic catabolic dysfunction. The homeostatic balance of joint is regulated by intracellular molecules such as kinase cascades， autophagy， and transcription factors， epigenetic mechanisms and extracellular stimuli including cytokines， hormones and mechanical stress. Exosomes， as a vesicle-like substance secreted into the extracellular environment， are widely involved in intercellular communication. Exosomes contain mRNAs， microRNAs and proteins and other bioactive molecules which can affect the progression of OA. Different stem cell-derived exosomes have some differences in their effects on OA. This article summarizes literatures about the effect of exosomes on OA in recent years to provide a further basis for the research of OA pathogenesis and treatment.
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