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The Physiological Function of Septin Protein Family and Its Effects on the Occurrence and Development of Septin-Associated Diseases
Zhang Jiajing, Yang Yang, Liu Ying, Guo Xiaoxi, Hao Qian, Yu Jiaojiao, Zhang Xinyu, Xu Tianrui*, An Shu*
Faculty of Life Science and Technology, Kunming University of Science and Technology, University Based Provincial Key Laboratory of Screening and Utilization of Targeted Drugs, Kunming 650500, China
Abstract: Septins are GTP-binding proteins and belong to GTPase superfamily. Septins are ubiquitously expressed in cells and are recognized as the fourth component of the cytoskeleton. As a component of the cytoskeleton， septins are involved in many physiological and pathological processes， such as yeast budding， cell division and host immune response. The abnormal expression and mutation of septin are closely related to the development of cancers and nervous system diseases. In this review， we focus on the research progress of the physiological functions of septins， and discuss its effects on the occurrence and development of cancers and nervous system diseases， and summarizes the recent findings about the role of septins in host immune response.
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