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Progress in the Study of Cardiomyogenic Differentiation of Mesenchymal Stem Cells
Liu Taidong, Huang Yan*
School of Biological Science and Medical Engineering, Beihang University, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing 100083, China
Abstract: Myocardial infarction is a kind of disease caused by irreversible necrosis of cardiomyocytes resulted from cardiac ischemia. Concurrently， using stem cells to treat myocardial infarction is more and more attractive. Mesenchymal stem cells (MSCs) are multipotent stem cells and commonly found in some interstitial tissues of human and animals， such as bone marrow and fat. Owing to their good ability to expand in vitro， the potential for multilineage differentiation and without ethical constraints， scholars have done numerous studies on how to differentiate MSCs into cardiomyocytes efficiently and selectively， so as to replace ischemic myocardium necrosis cells in patients’ body. To yet， it has been found that in vitro induction of MSCs to differentiate into cardiomyocytes mainly use chemical agent induction， biological factor induction， physical induction， co-culture induction and molecular manipulation induction (transfer miRNA and transcription factor). This article mainly summarizes the above five methods in order to understand the current research status in inducing cardiomyogenic differentiation of MSCs in vitro.
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