Home > Browse Issues > Vol.29 No.6
Progress in Mitotic Catastrophe
Bo Zhang1,2, Ping-Kun Zhou2*
1Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850, China; 2Prologue and Veterinarian Institution, Shenyang Agricultural University, Shenyang 110161, China
Abstract: Cell death is an important physiology and pathology phenomenon to the multi-cellular organisms. The cell death can be categorized into necrosis and programmed cell death (PCD). PCDs include apoptosis， autophagic cell death and mitotic catastrophe， each with different morphological changes and biochemical mechanistic pathways. The mitotic catastrophe was most recently recognized and described， and it characterizes as a cell death occurred during mitosis due to abnormal mitotic progress， usually accompanying with abnormal cell cycle checkpoint and genomic or spindle lesion. Herein we review the related molecular mechanisms regulating the mitotic catastrophe.
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